Prevalence and Risk Factors Associated with Prehypertension among Young and Middle-Aged Health Check-Up Population in Guangzhou

Objective: To provide basic information and theories for prehypertension early intervention, a systematic analysis of the epidemic status and risk factors among young and middle-aged was carried out here. Methods: This study relied on the data bank of a health check-up population of a class a tertiary general hospital in Guangdong province in 2015. Total 9540 young and middle-aged adults were enrolled, and 733 people were included to find out the effect with lifestyle in these crowd. Principal Components Analysis (PCA) of Factor (FA) was used to identify dietary patterns. The logistic regression model was used to find the risk factors of prehypertension. Results: Among 9540 young and middle-aged cases, the incidence of prehypertension was 36.6%. Moreover, the average age, proportion of male gender, overweight, FBG (fasting blood glucose), dyslipidemia, and hyperuricemia were significantly higher in the prehypertension group than in the optimal BP group. Multivariate logistic regression analysis indicated that age, total cholesterol, triglycerides, uric acid, body mass index and HR (heart rate) were risk factors, and female was a protective factor for prehypertension. Among 733 cases, the incidence of prehypertension was 35.1%. The proportion of smoking, drinking, physical workers, moderate and severe physical activity, and the intake of meat, dietary energy were significantly higher in the prehypertension group than in the optimal BP group. Dietary patterns included “meat model”, “spice model”, “main vegeTables model” and “high protein model”. Multivariate logistic regression analysis indicated that age, drinking were risk factors for prehypertension, while dietary milk intake, dietary magnesium intake were protective factors. Conclusions: Prehypertension is highly prevalent in Guangzhou. However, education about effective lifestyle modifications as an alcohol limit, increasing the intake of dairy products, and magnesium may intervene in the development of prehypertension. But how to develop targeted interventions for such groups need to be further explored. The present study would lay the theoretical foundation and basic data for the next step

Lake storage variation on the endorheic Tibetan Plateau and its attribution to climate change since the new millennium

Citation: Yao, F., Wang, J., Yang, K., Wang, C., Walter, B. A., & Crétaux, J.-F. (2018). Lake storage variation on the endorheic Tibetan Plateau and its attribution to climate change since the new millennium. Environmental Research Letters, 13(6), 064011. https://doi.org/10.1088/1748-9326/aab5d3Alpine lakes in the interior of Tibet, the endorheic Changtang Plateau (CP), serve as ‘sentinels’ of regional climate change. Recent studies indicated that accelerated climate change has driven a widespread area expansion in lakes across the CP, but comprehensive and accurate quantifications of their storage changes are hitherto rare. This study integrated optical imagery and digital elevation models to uncover the fine spatial details of lake water storage (LWS) changes across the CP at an annual timescale after the new millennium (from 2002–2015). Validated by hypsometric information based on long-term altimetry measurements, our estimated LWS variations outperform some existing studies with reduced estimation biases and improved spatiotemporal coverages. The net LWS increased at an average rate of 7.34 ± 0.62 Gt yr−1 (cumulatively 95.42 ± 8.06 Gt), manifested as a dramatic monotonic increase of 9.05 ± 0.65 Gt yr−1 before 2012, a deceleration and pause in 2013–2014, and then an intriguing decline after 2014. Observations from the Gravity Recovery and Climate Experiment satellites reveal that the LWS pattern is in remarkable agreement with that of regional mass changes: a net effect of precipitation minus evapotranspiration (P-ET) in endorheic basins. Despite some regional variations, P-ET explains ∼70% of the net LWS gain from 2002–2012 and the entire LWS loss after 2013. These findings clearly suggest that the water budget from net precipitation (i.e. P-ET) dominates those of glacier melt and permafrost degradation, and thus acts as the primary contributor to recent lake area/volume variations in endorheic Tibet. The produced lake areas and volume change dataset is freely available through PANAGEA (https://doi.pangaea.de/ 10.1594/PANGAEA.888706)

Hydrogen-rich water treatment improves fresh-cut Gastrodia elata quality by regulating reactive oxygen species metabolism and energy metabolism during low temperature storage

The application of hydrogen-rich water (HRW) can extend the shelf life of fruits and vegetables. This study aims to investigate the effects of HRW on the quality of fresh-cut Gastrodia elata during low-temperature (4°C) storage. The results indicate that HRW treatment inhibited the decrease in weight loss and the increase in respiration rate, and also slowed down the decrease in total acidity and total soluble solids. HRW treatment could reduce the generation of superoxide anions and hydrogen peroxide, enhance the activity and expression of antioxidant-related enzymes such as superoxide dismutase, catalase, ascorbate peroxidase, glutathione reductase, monodehydroascorbate reductase, and dehydroascorbate reductase, and increase the content of non-enzymatic antioxidant substances, ascorbic acid and glutathione, while decreasing the activity and expression of peroxidase and polyphenol oxidase. Furthermore, HRW treatment not only inhibited the reduction in ADP and ATP content and energy charge but also attenuated the increase in AMP content. It also slowed down the decrease in the activities of H+-ATPase, succinate dehydrogenase, Ca2+-ATPase, and cytochrome C oxidase. In conclusion, these results demonstrate that HRW treatment enhances the energy levels and effectively mitigates oxidative damage, thereby preserving postharvest quality of fresh-cut G. elata

Differences in metabonomic profiles of abdominal subcutaneous adipose tissue in women with polycystic ovary syndrome

IntroductionPolycystic ovary syndrome (PCOS) is a complex endocrine disorder that often coexists with a metabolic disorder. Studies have demonstrated that the malfunction of adipose tissue, particularly abdominal adipose tissue, could exacerbate reproductive and metabolic problems in PCOS patients. Adipose tissue-secreted signaling mediators (e.g., lipids and metabolites) would then interact with other body organs, including the ovary, to maintain the systemic equilibrium.MethodsIn this study, we examined adipose samples from PCOS patients and unaffected individuals using a liquid chromatography–mass spectrometry-based metabonomics approach (LC–MS/MS). PCOS biomarkers were selected using multivariate statistical analysis.ResultsOur pathway analysis revealed that these differential metabolites could be engaged in inflammatory diseases and mitochondrial beta-oxidation. We further developed an in vitro PCOS cell model to examine the effects of hyperandrogenism on granulosa cells and related metabolic disorders. We noted that isoleucine recovered the promotive effect on cell apoptosis, inhibitory effect on cell proliferation, sex hormone secretion, and mitochondrial function induced by dehydroepiandrosterone. Our gas chromatography–mass spectrometry targeted analysis (GC–MS/MS) revealed that isoleucine was significantly decreased in PCOS patients.DiscussionBased on these results, we speculate that metabolome alterations are vital in ameliorating PCOS symptoms. This may be a novel therapeutic target for PCOS treatment. Our study provides preliminary evidence that these findings will enhance our ability to accurately diagnose and intervene in PCOS

What is learning in service-learning? Findings from service-learning research at Beijing Normal University

What is learning in service-learning? The question was put forward decades ago but has not been answered clearly in the international context. Focused on this important issue, we conducted a series of studies with mixed method approach. We surveyed 844 college students and 6203 middle school students respectively in mainland China. Results indicated that most students had some experience of service activities. However, the quality of such practice was not satisfying in the aspects of duration, intensity and link to curriculum. Based on the above investigation, we conducted a service-learning program through the course of Psychology of Learning for undergraduate students of Psychology Department in Beijing Normal University. The instructor, together with teaching assistants who had rich experience on special education, gave a two hour lecture in class each week and guided students to interact with special children (the mentally retarded, autism) in groups at weekend during one semester. Following the basic procedure of service-learning, students were encouraged to apply what they learned in classroom to the service practice and to reflect the effectiveness of their behavior modification plans for special children as well as their own thoughts, feelings and behaviors during interactive process. Especially, students were asked to think critically about issues on inclusion, welfare and social support for special children and their families. Students received feedbacks on their reflection journals and discussions after every service practice. This program had been conducted for about 3 semesters successively in BNU and more than 200 undergraduate students engaged in it. Data were collected and analyzed from interactive video, group discussion and focused group interview, self-report surveys, reflection journals and feedbacks from parents of special children. In general, the program had great effects on students’ attitude to special children and their families. Students showed significant change from unconcerned, wondering, sympathetic, or credit-driven at the beginning to caring, patient, empathetic, and problem-solving driven at the end of service practice. Results also indicated that service-learning improved students’ higher cognitive abilities such as transfer abilities of problem solving, critical thinking and students’ academic expertise, such as Applied Behavior Analysis skills

Plasma Heme Oxygenase-1 Concentration is Elevated in Individuals with Type 2 Diabetes Mellitus

Background: Circulating concentrations of heme oxygenase-1 (HO-1) have been recently reported to be elevated in several chronic disorders. However, no study has ever examined the association between circulating HO-1 concentrations and type 2 diabetes mellitus (T2DM). Methods and Findings: 581 cases with newly-diagnosed T2DM (New-T2DM) and 611 comparison controls were recruited in this two-phase case-control study, comprising 420 cases and 429 controls collected in the first phase study and 161 cases and 182 controls in the second phase replication study. Analyses, using both separated data and combined data from the two-phase studies, show that plasma HO-1 concentrations were significantly increased in New-T2DM cases compared to controls (P less than 0.001). Plasma HO-1 concentrations were significantly correlated with plasma glucose concentrations, HOMA-beta and HOMA-IR (P less than 0.001). After adjustment for age, sex, BMI and family history of diabetes, the ORs for New-T2DM in the highest quartile of plasma HO-1 concentrations, compared with the lowest, was 8.23 (95% CI 5.55–12.21; P for trend <0.001). The trend remained significant after additional adjustment for fasting plasma glucose/insulin, HOMA-beta/HOMA-IR, TC/TG, smoking, drinking and history of hypertension, and even in further stratification analysis by age, sex, BMI, smoking, drinking and history of hypertension. Conclusions: Elevated plasma HO-1 concentrations are associated with higher ORs for New-T2DM, which add more knowledge regarding the important role of oxidative stress in T2DM. More consequent studies were warranted to confirm the clinical utility of plasma HO-1, especially in diagnosis and prognosis of T2DM and its complications

Preeclampsia in pregnant women with polycystic ovary syndrome: risk factor analysis based on a retrospective cohort study

Objectives: To compare the clinical characteristics of pregnant women with polycystic ovary syndrome (PCOS) and perinatal outcomes with or without preeclampsia (PE) and to factors that are potentially associated with the onset of PE. Material and methods: This was a retrospective study of pregnant women diagnosed with PCOS from January 2017 to December 2021. Eligible patients were divided into two groups based on the presence or absence of preeclampsia: a PE group and a non-PE group. Demographics, clinical characteristics, maternal and perinatal outcomes, and potential factors linked to disease recurrence were analyzed. Results: In total, 616 patients were enrolled and respectively classified into the PE group (n = 51) and the non-PE group (n = 565). The incidence of PE in pregnant women with PCOS was 8.28%; this was significantly higher than that in non-PCOS pregnant women (3.22%, p &lt; 0.001). Logistic regression analysis of the predictive factors for PE in women with PCOS revealed that the combination of maternal hyperandrogenism, a pre-pregnancy BMI ≥ 24 kg/m2, and a family history of cardiovascular disease (CVD) and assisted reproductive techniques (ART) exhibited the steepest receiver-operating characteristic (ROC) curve value at 0.797 [95% confidence interval (CI): 0.733–0.862]. Conclusions: Patients with PCOS have a higher incidence of PE. We identified a series of significant and independent factors associated with PE in PCOS: maternal hyperandrogenism, a pre-pregnancy BMI ≥ 24 kg/m2, and a family history of CVD and ART

ATF4 Contributes to Ovulation via Regulating COX2/PGE2 Expression: A Potential Role of ATF4 in PCOS

Ovulatory disorder is common in patients with hyperprolactinemia or polycystic ovary syndrome (PCOS). Previous studies have shown that ATF4 plays critical role in apoptosis and glucose homeostasis, but its role in regulating reproductive function was not explored. The present study investigated the role of ATF4 in ovarian ovulatory function. Human granulosa cells (hGCs) from 48 women newly diagnosed with PCOS and 37 controls were used to determine ATF4 expression. In vitro cultured hGCs were used to detect the upstream and downstream genes of ATF4. A shRNA- Atf4 lentiviral vector (shAtf4) was injected into rat ovaries to establish an in vivo gene knockdown model to further assess the in vivo relevance of the results from PCOS women. We found that ATF4 expression was lower in hGCs from PCOS patients than in hGCs from non-PCOS women. Many pivotal transcripts involved in cumulus-oocyte complex (COC) expansion, extracellular matrix (ECM) remodeling, and progesterone production were significantly down-regulated after ATF4 knockdown. ChIP-qPCR assays indicated that ATF4 could directly bind to the COX2 promoter and that ATF4 knockdown could attenuate human chorionic gonadotropin (hCG)-induced COX2 expression and PGE2 production. The in vivo study showed that shRNA-lentivirus mediated Atf4 knockdown in rat ovaries led to reduced number of retrieved oocytes. Collectively, these findings suggested previously unknown roles of ATF4 in ovulation. Furthermore, ATF4 malfunction in PCOS patients may impact the ovulation process, which could contribute, in part, to the pathogenesis of PCOS

Towards Exascale Computation for Turbomachinery Flows

A state-of-the-art large eddy simulation code has been developed to solve compressible flows in turbomachinery. The code has been engineered with a high degree of scalability, enabling it to effectively leverage the many-core architecture of the new Sunway system. A consistent performance of 115.8 DP-PFLOPs has been achieved on a high-pressure turbine cascade consisting of over 1.69 billion mesh elements and 865 billion Degree of Freedoms (DOFs). By leveraging a high-order unstructured solver and its portability to large heterogeneous parallel systems, we have progressed towards solving the grand challenge problem outlined by NASA, which involves a time-dependent simulation of a complete engine, incorporating all the aerodynamic and heat transfer components.Comment: SC23, November, 2023, Denver, CO., US